Quadro Engineering is active in many areas relating to the pharmaceutical OSD manufacturing processes, including:
When manufacturing pharmaceutical OSD products, powder processing is a key consideration that ultimately affects the quality and dosage of the end product. The mill type and specifications you choose directly influence not only particle size distribution, but also particle morphology, surface area, flowability, compressibility, blend uniformity, and granule quality. For pharmaceutical manufacturers, mill selection must therefore be based on both the properties of the feed material and the target particle characteristics required downstream, whether the goal is improved content uniformity, reliable compression, tighter dissolution performance, or better bioavailability.
Across each stage of development, whether that be testing new formulations at the lab scale, or mass-producing tablets commercially, manufacturers need equipment that can deliver repeatable performance in order to deliver the expected result for consumers while supporting cGMP compliance, cleanability, containment, and efficient scale-up.
The main challenges in OSD powder processing and wet granulation include maintaining target PSD, ensuring consistent powder flow, protecting heat-sensitive APIs, containing potent materials, and scaling processes without drift, yield loss, or excessive downtime.
Wet and dry milling also introduce different tradeoffs: wet milling can help control particle breakage while limiting some dry handling issues, whereas dry milling can be more efficient for certain size reduction duties but may introduce added heat, static, or fines depending on the material and mill type.
As an industry leader in milling and powder processing technology, we provide unparalleled particle processing efficiencies, enabling pharmaceutical customers to deliver more of their valuable product on target and manufacture it with higher capacities.
We improve our customers’ profitability by helping to reduce waste and rework, saving not only expensive ingredients but also manufacturing time. We aim to improve product quality by ensuring that the OSD powder is correctly conditioned so that it is successfully compressed into tablets.
We understand how the Particle Size Distribution (PSD) and bulk density of powders impact flowability to the tablet press and subsequent dissolution rate & bioavailability of the finished tablet.
The ability to produce a tight particle size distribution suitable for compaction and dissolution is dependent upon selecting the right technology for the application, whether that be:
and controlling the equipment elements:
In addition, we offer equipment that will carefully handle heat-sensitive products so that they are not degraded in the milling or screening process.
Wet mass conditioning is a key application of our mills and has been proven to be vital to creating a quality final tablet.
We have extensive expertise, which has been gained from over 10,000 installations around the world, in addition to the thousands of customers we have assisted over the years - both Fortune 500 and small independents.
We recommend that our R&D Test Center conduct proof of concept testing on our fleet of equipment for testing at your own premises over a longer period of time.
We offer our own training programs, which are ideal to send new starters on to learn about milling and particle processing. We are also proud to sponsor and contribute to industry initiatives and academic support, often presenting Papers at Conferences.
The support team you will have access to comprises our worldwide Process & Application Specialists who are ready to help optimize your system and solve your powder processing problems.
Our Sales, Engineering, and Aftermarket support comes not just from Head Office in Canada, but also from our physical presence in strategically important regions that make sure you not only get the ideal system but can maintain it in tip-top condition.
Our equipment solutions provide proven scalability, helping you transfer results and parameters from lab-scale to production-sized equipment with repeatable and reproducible PSD and capacity targets, thereby reducing development time and launch costs.
Over the past several decades, we have been involved in a variety of industries, in addition to pharma, including:
We are happy to discuss your manufacturing concerns and offer personalized advice to help you find the right size reduction solution for your goals. Get in touch with our team or explore our other resources below.
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