Pharma Milling Equipment for Size Reduction

1.1 EFFICIENT CLEANING METHODS

Cleaning Techniques for Particle Sizing and Milling Equipment

In pharmaceutical manufacturing, strict cleaning processes are required to prevent contamination and comply with regulations.

Maintaining rigorous cleaning standards for milling and particle sizing equipment is fundamental to ensuring product quality, meeting regulatory requirements, and protecting your operation from costly contamination risks. In this article we outline proven methods and practical tips to enhance cleaning efficiency while safeguarding compliance.

1.2 CHOOSING THE RIGHT MILL SCREEN

Choosing the Correct Mill Screen for Your Bulk Powder Solids

Adjusting parameters like screen type, size, and impeller speed helps achieve the desired particle size and minimize waste.

Key considerations when choosing a conical mill screen include hole type & size, impeller arm profile, impeller tip velocity and RPM, and feeding method. Gain practical insights about selecting the right screen and milling parameters to help you maintain high product quality and optimize your manufacturing workflow.

1.3 COMPLIANT PHARMACEUTICAL MANUFACTURING

cGMP Milling with Low Heat and No Contamination

Greaseless gearboxes ensure product integrity, reduce the need for frequent maintenance, and support streamlined cleaning protocols.

Whilst not a common occurrence, some mills can contaminate the final product with grease if the shaft seal becomes worn or damaged, resulting in high product wastage. Greaseless gearboxes support cleaner processing environments and help manufacturers comply with rigorous hygiene standards by eliminating the risk of grease contamination. This leads to greater operational efficiency, lower production costs, and enhanced confidence in the quality and safety of your pharmaceutical products.

1.4 SCALING UP PRODUCTION

How to Scale Up Your Milling Process as Production Needs Increase

What are the most important factors to evaluate when scaling up to larger volumes?

2.1 IMPORTANCE OF PSD

Why is Particle Size Distribution Important in API Pharmaceuticals?

Controlling particle size is essential to API bioavailability and shelf life; smaller, consistent particles are increasingly more desirable.

In pharmaceutical manufacturing, controlling particle size distribution (PSD) is crucial to the dissolution rate, bioavailability, and shelf life of active pharmaceutical ingredients (APIs). When it is not properly controlled, manufacturers can face issues such as poor flowability, inconsistent drug release, and reduced product stability, which may lead to failed batches, increased waste, and compliance risks. This is especially important for potent compounds and complex formulations where even minor variations can impact efficacy and safety.

In this blog, we outline the key considerations and processes for managing particle size distribution in active pharmaceutical ingredients.

2.2 THE QUADRO FINE GRIND

Effective Fine Particle Size Reduction and Milling

Achieve advanced size reduction with minimum fines and overs as compared to traditional methods.

The Quadro Fine Grind Model F10 is an advanced milling solution that delivers superior fine particle size reduction with fewer fines and overs compared to traditional methods. It enables pharmaceutical manufacturers to achieve greater efficiency, precision, and consistency in producing high-quality powders.

3.1 WHAT IS WET GRANULATION

Powder Milling Technology for Dry and Wet Processes

When to choose wet granulation for your process and its role in achieving optimal particle size for tablet manufacturing.

Wet granulation is an essential technique in tablet manufacturing, used to bind fine powders into larger, uniform granules by introducing a liquid binder. This process enhances particle size distribution, improves flowability, and delivers superior compressibility—critical factors for achieving consistent, high-quality tablets in the food, pharmaceutical, and chemical industries. Read our blog to explore the key benefits of wet granulation and when to choose it for your process.

3.2 IMPROVING EFFICIENCY WITH WET GRANULATION

Reducing Drying Times in the Wet Granulation Process

How a Quadro customer improved their wet granulation process.

Read our bulletin to learn how Quadro equipment improved this customer's wet granulation process, streamlining particle sizing and optimizing efficiency by minimizing drying times and enhancing batch consistency.

3.3 PHARMACEUTICAL TABLET RECLAIM

Efficient Tablet Reclaim

Avoiding unnecessary waste and expense in OSD manufacturing with tablet reclaim.

Strict quality control standards and stringent Quality Assurance testing in the pharmaceutical OSD process will often result in tablets being judged unfit for sale - they may be too soft, too hard, broken, off-spec, etc. Efficient tablet reclaim with the Quadro® Comil® in pharmaceutical manufacturing can help reduce material loss and overall production costs.

3.4 DRY GRANULATION APPLICATION BULLETIN

Dry Granulation Sizing Prior to Tableting

Increasing production capacity when producing pharma OSD products.

By integrating an in-line Quadro Comil, this customer more than doubled their production capacity, efficiently reducing oversized particles from the blender while maintaining consistent particle size distribution in the rest of the material.