Conical milling (or cone milling) is one of the most common methods of milling in pharmaceutical manufacturing and associated industries. In pharmaceutical production, Conical mills are typically used for size reduction and deagglomeration or delumping of powders and granules, with the goal of achieving a desired particle size distribution (PSD).
Generally used for reducing material to a particle size as low as 180µm (80 mesh), Quadro Comil® conical mills produce less dust (waste) and heat than other mill types.
Utilizing decades of experience from the team at Quadro Engineering, and with the gentle grinding action and quick discharge of correctly sized particles, a Comil will ensure pharmaceutical customers can quickly—and consistently—achieve the PSDs they desire for OSD and API production.
Conical milling: How it works
Quadro invented the original conical mill in 1976. Though simple in principle, the Comil was a revolutionary concept that has since evolved into a global processing standard adopted by market leading pharmaceutical manufacturers around the world.
Each Comil model comprises of a vertically mounted rotating impeller which moves material across a milling screen causing a low velocity cutting action on the particle.
Operating parameters of screen size and type, impeller style and size, and tip speed is needed to reach a desired particle size distribution (PSD). Quadro’s experienced team of sales engineers can assist customers in creating the ideal parameters for a particular product.
Once the operating parameters are set, pre-milled material is fed by gravity into the top of the mill head. Because Comils can easily accept flood feeding—operators don’t need to worry about meter feeding their product.
Under operation, if particles are already the desired size they will pass through the screen and will be discharged immediately. If not, particles will be manipulated in the cutting chamber until they reduce down to the predefined size that allows them to pass through the screen.
The Comil’s low RPM, low-energy, low-heat and low-noise design makes the mill the ideal solution for pharmaceutical particle size reduction applications—especially those with temperature sensitivity. The ability to be choke (flood) fed results in low dust, low product waste, and high throughput. Once processed with the Comil, tight particle sizing helps improve flowability and uniformity of powders before they enter the tablet press.
Comil conical mills are the perfect solution for a range of pharmaceutical applications
Quadro manufactures a range of cone mills from labscale through to full capacity production machines, utilizing both Overdriven and Underdriven drive options. Based on the application and material properties that you require during the development of pharmaceutical OSDs and APIs (such as particle size, moisture content, temperature sensitivity, hardness, and more) our sales engineers can help you get to full production quickly.
Comil conical mills are widely used in the manufacture of:
Comil conical mills are well known for helping manufacturers achieve PSDs optimized to produce the correct level of compressibility for the tableting process. Comils ensure OSD manufacturers the flexibility and speed they need to reliably produce top quality product consistently, and competitively with no downtime or waste.
In new drug development, particle size is crucial in driving the bioavailability and stability of the API. Comils make sure that manufacturers can achieve smaller particle sizes and tighter PSDs than other types of mill, with far less waste generated for improved profitability.
The Overdriven Comil Series: high volume capacity with low cost of ownership
The Quadro Comil Overdriven Series offers a range of production capacities from small scale (ideal for testing) to high volume with consistent particle size distributions, less generated waste and a low total cost of ownership due to simple maintenance. The Overdriven series has an unequaled track record for high-efficiency inline processing for pharmaceutical OSDs and APIs.
The Comil Overdriven range is simple and economical to maintain and operate. Machines are ideal for hand feeding and delumping applications, and operators are able to make fast screen and impeller changovers due to the user-friendly design and operation. The sanitary design and easy-to-clean construction methodology leads to faster maintenance and less downtime.
Quadro Engineering offer the largest number of screen and impeller combinations in the market. With assistance from our highly qualified team of sales engineers, the perfect screen, impeller and tip speed combination can be identified for all types of particle product, enabling customers to get up to full production faster and easier.
All Comils feature the following benefits:
Gentle handling of product
The low RPM, low energy and low heat operation of our Comil units make them a perfect solution for pharmaceutical applications, enabling consistent, safe and productive milling of APIs and heat sensitive products. Quadro Engineering have built a global reputation for enhancing production methods and processes for pharmaceutical manufacturers with Comil conical mills.
Easy disassembly and a design with no entrapment areas means that Comil mills are simple to maintain, keeping downtime to a minimum for higher profitability.
Whatever your capacity requirements, we have a Comil that can match or exceed your needs. And when your capacity requirements grow, you can easily scale up, transfer the operating parameters to your larger Comil machine, and produce product with exactly the same results as before.
Safe product handling
The highly efficient operation of the Comil generates less dust than other milling methods leading to a cleaner environment with less risk of contamination.
Unequalled production capacity
Due to Comil’s plug-feeding capability, and the ability to be choke or flood fed, Comil’s output capacity is unrestricted and there is no need for a metered feeding system.
Quadro manufactures a range of Comil conical mills from lab scale to full capacity.
Whether users have smaller production needs, or full capacity production requirements there are Comils available to match your required output. And as your production increases, it is a simple process and calculation to scale up to a larger capacity unit using the same parameters. You will be able to process the same type of product and get exactly the same results, every time, at a much larger capacity than before.
Overdriven Comil is currently offered in the following sizes:
197 Overdriven Comil for smaller scale production
194 Overdriven Comil for mid-range capacities
196 Overdriven Comil for production scale
198 Overdriven Comil for large volume scale
Comil conical mills are integrated into Quadro’s new interchangeable head processing platforms
With Comil well established as the industry standard for pharmaceutical conical milling, Quadro are constantly developing new products to help pharmaceutical manufacturers get the flexibility they need in their production workflows.
Quadro now have two flexible interchangeable head platforms that offer unmatched flexibility to pharmaceutical manufacturers:
The SLS – Scalable Lab System™. Experiment with different powder processing and milling options on smaller batches.
R&D labs and production firms need the latest cutting-edge technologies for milling, while keeping capital equipment expenses as low as possible. The SLS comes at the right time.
The SLS is a highly versatile, advanced benchtop, multi-purpose powder milling and screening platform with interchangeable heads on one common drive.
Operators can quickly experiment with, and switch between different processes and then reach their testing and research goals faster—all with a low investment. When they’re ready to go to full production, their process results can be matched exactly on our range of production capacity equipment.
The SDx Series™. Empowering production scale milling versatility with strict budget control.
Pharmaceutical manufacturers need their powder processing equipment to be flexible, highly efficient, and with a low total cost of ownership. The SDx Series ticks all the boxes.
The SDx Series is the most advanced powder processing platform with three interchangeable heads, allowing operators to quickly switch between several distinct powder processing and milling operations in seconds.
Changing the processing head (rather than having to work across several machines) allows users to switch between conical milling, hammer milling or sifting, and work faster producing several batches at once. The SDx replaces three separate workstations, all with their own space, operator and power requirements.
Customers benefit from Quadro’s wealth of experience
With thousands of equipment installations around the world, the team at Quadro have earned the respect of customers globally. And because we manufacture the industry’s most extensive and flexible line of conical milling equipment, we also have the largest range of screens and impeller/rotor options to suit all powder milling and processing applications.
Quadro’s extensive selection of Screen types and sizes accommodate most particle size requirements. Screens are available with openings as small as 0.150mm (0.006”), and as large as 38mm (1.5”). Screen choices are extended further with options for round or square perforations, wire mesh or for grater or Conidur holes.
Dozens of different profiled Impellers can also be used to suit the specific application requirements. Basic options include round arm, square arm, or beveled arm impellers. More aggressive profiles are also available. Impellers can be further enhanced with available special finishes and add-ons.
Our team travels around the world to help customers optimize their processes and get the results they need. Our in-house experts have decades of experience in helping customers select the perfect equipment parameters. Experience counts for everything.
If you’d like a demonstration of our products, please contact us and we’ll put you in touch with a local sales engineer.