Skip to content

1 Min Read Time


Wet Granulation With a Comil (Conical Mill) Reduces Material Drying

Using the Wet Granulation Method

Pharmaceutical companies worldwide have been using the Comil® (original conical screen mill) for removing lumps from pharmaceutical wet masses prior to the drying process.

In the tablet manufacturing process, powders such as lactose, the active ingredient, binders, and water or solvent are mixed to form a wet mass. This process can be carried out in various types of mixers. The high shear mixer/granulator is often used to mix and granulate this wet mass.

When blending active ingredients, binders, and water or solvent in a high shear mixer/granulator it forms irregularly sized lumps which, if not de-agglomerated, result in longer drying times and poorer particle size distributions.

Wet Mass Particle Size Reduction: Case Study

A large, North American pharmaceutical company had approached Quadro with an application to remove lumps from a pharmaceutical wet mass (lactose + active ingredient).  Their high shear mixer was discharging material containing lumps of up to 4 inches in diameter (100 mm).  These lumps, when passed through a dryer, would not dry all the way through.  This caused case hardening, uneven moisture distribution, and some product over-drying due to the excessive time required to completely dry the larger lumps.

The large hard lumps with moist centers also caused problems in milling after the dryer. When milling over-dried lumps it often leads to the unwanted generation of excessive fines (which result in poor powder flowability).

The Quadro Solution

Model U30  Quadro<sup>®</sup> Comil<sup>®</sup>

The Model U30  Quadro® Comil® was able to accept the direct discharge of the mixer on a “choke” (flood) feed basis at a capacity of 10,000 lb/hr (4,500 kg/hr). Discharge from the Comil® consisted of a free-flowing granular product that was 100% (-) 4 mesh U.S. standard.

The Results

Due to the greatly enhanced surface area of the wet product produced by the Comil®, the drying time using a tray dryer was reduced by 60% compared to the previous method. 

This enabled the manufacturer to save money as they were spending less on fuel for drying and labor reduction. In addition, the company freed up more production capacity achieving greater efficiencies

As the material dried evenly and quickly. Product over-drying was no longer a problem. This meant less wasted product. Downstream dry milling has also been greatly enhanced with the use of a Comil®.

For more best practices on Particle Size Reduction Mills and Sizing Equipment please visit our knowledge base page.

(Ref: AP3R2 Sizing Wet Granulation prior to drying)

Download AB Sizing Wet Granulation Reduces Drying Times
Posted by Kathryn Perry
Find me on:


Blog articles direct to your inbox




Request a call back or email response

For more information, please contact our team via the form below and a representative will contact you to answer any questions. Phone inquiries can also be made +1-519-884-9660.

Quadro has earned the respect of customers with a wide variety of applications in more than 80 countries. Our recognized leadership in specialized process equipment was launched by a single idea in 1976 that has stood the test of time.