Quadro Blog / Articles

Pharmaceutical Milling applications for the Quadro Comil Conical Mill

Published on Nov 28, 2019 4:09:04 PM

Typical Milling Pharma Applications

Pharmaceutical companies worldwide are successfully using the Quadro® Comil® for wet granulation mixes before drying, sizing after drying, granulating in the pre-compression stage, homogeneous mixing, conditioning, and dispersion of pigments in the manufacture of tablets.

 

Wet Granulation Sizing

wet lumpy granulations
  • The Comil® is designed to take wet lumpy granulations and uniformly size them at very high capacities.
  • Sizing or de-lumping wet granulations ensures equally sized granules are introduced into driers, thus eliminating case hardening and helping granules to dry uniformly and more rapidly.
  • Uniform particle size distributions prevent fines and potentially un-even die filling or sticking at the punches during tableting.

 

Double CompressionDouble Compression using a roller compactor

  • Direct compression blends are pre-compressed, granulated, then pressed into tablets. Ribbons from the roller compactor or slugs from pre-compression can be size reduced with a Comil® to granules with optimum particle size distribution.

 

Dried Granulation SizingDried Granulation Sizing using the Comil

  • The Comil® sizes dry granulation material to the optimum particle size distribution for efficient tableting.

Tablet/Capsule ReclaimTablet Reclaim re sizing

  • “Off spec” tablets are size reduced for reclaim purposes. “Off spec” capsules are broken into large pieces allowing for easy separation of powder from the gelatin pieces.

 

Ingredient Conditioning

ingredient conditioning using the mill

  • Ideal for a broad range of de-lumping, mixing, finishing and milling.
  • Lump-free homogeneous dry ingredient blending.
  • Low heat build-up and precise screen size ensure complete dispersion, at desired particle size.

 

The benefits of the Comil®

  • Low dust
  • Low noise
  • Low heat
  • Fewer fines
  • Short changeover times
  • High capacities
  • Easy, fast cleaning

(Ref: AP16 Comil® Pharmaceutical Applications)

Learn more about Quadro's Technology, Particle Processing, Particle Size Reduction, Mills and Milling Technology via our knowledge hub page, containing a range of useful articles and guides. Or to contact a member of the Quadro Engineering team please contact us.

 
Download AB Typical Pharmaceutical applications Comil
Posted by Kathryn Perry
Find me on:
LinkedIn

Topics: Dry Granulation, Double Compression, Powder Conditioning, Comil, Production Efficiency, Wet Granulation, Tablet Reclaim